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KMID : 1161420130160070593
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Journal of Medicinal Food
2013 Volume.16 No. 7 p.593 ~ p.601
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Comparative Protective Effect of Hawthorn Berry Hydroalcoholic Extract, Atorvastatin, and Mesalamine on Experimentally Induced Colitis in Rats
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Malekinejad Hassan
Shafie-Irannejad Vahid
Hobbenaghi Rahim
Tabatabaie Seyed Hamed
Moshtaghion Seyed-Mehdi
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Abstract
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The protective effect of hydroalcoholic extract of hawthorn berries (HBE) on acetic acid (AA)?induced colitis in rats was investigated. Forty-two Wistar rats were divided into seven groups, including control and test groups (n=6). The control animals received saline, and the test animals were treated with saline (sham group), mesalamine (50?mg/kg; M group), atorvastatin (20?mg/kg; A group), HBE (100?mg/kg; H group), mesalamine and HBE (HM group), or atorvastatin plus HBE (HA group), 3 days before and a week after colitis induction. Colitis was induced by administration of 1?mL AA (4%) via a polyethylene catheter intrarectally. High-performance liquid chromatography analyses showed that HBE contained 0.13% and 0.5% oleanolic acid and ursolic acid, respectively. Elevated myeloperoxidase activity and lipid peroxidation were attenuated in the HA group. The H and HM groups showed marked reductions in colitis-induced decreases in total thiol molecules and body weight. The histopathological studies revealed that HBE decreased colitis-induced edema and infiltration of neutrophils. Our data suggest the anti-inflammatory and antioxidant effects of HBE and atorvastatin protect against AA-induced colitis. The anti-inflammatory effect of HBE may be attributable to its ability to decrease myeloperoxidase activity as a biomarker of neutrophil infiltration.
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KEYWORD
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acetic acid-induced colitis, antioxidant status, hawthorn berries extract, histopathological examinations, myeloperoxidase activity
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